Name: Thiamphenicol
Price: 171.00 USD

- Overview
  - Thiamphenicol is a bacteriostatic antibiotic derived from chloramphenicol. Like chloramphenicol, thiamphenicol is insoluble in water but highly soluble in lipids.
    
    Please contact us at for specific academic pricing.
    
    Background
    
    Both thiamphenicol and chloramphenicol work by the same mechanism, however, thiamphenicol is about 3X as potent. After entering a bacterial cell, thiamphenicol binds to the 50S ribosomal subunit preventing peptide bond formation. Resistance to thiamphenicol may be due to decreased cell permeability or a mutation in the 50S ribosomal subunit.
- Properties
  - CAS Number
    
    15318-45-3
    
    Molecular Formula
    
    C12H15Cl2NO5S
    
    Molecular Weight
    
    356.22 g/mol
    
    Appearance
    
    Off-white powder
    
    Solubility
    
    Acetonitrile: SolubleAlcohol: SolubleDimethylacetamide: SolubleDimethylformamide: Soluble Water: Slightly soluble
    
    Other Properties
    
    Source: Synthetic
    Absorbance: UV max (95% ethanol): 224, 266, 274 nm (ε 13,700, 800, 700).
    Melting Point: 164.3-166.3 °C
    Purity Level: ≥98.0%
    
    Storage
    
    2-8 °C, protect from light
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Thiamphenicol is a broad spectrum antibiotic commonly used to target bacteria responsible for causing sexually transmitted diseases.
    
    Microbiology Applications: Thiamphenicol is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:Neisseria gonorrhoeae 0.125 µg/mL – 4 µg/mL
    
    Plant Biology Applications: In a study by Meynier et al. (1989), thiamphenicol was used for hygienic purposes in hybrid walnut propagation. In addition to other antibiotics used during the study, thiamphenicol was found to be effective against several gram negative pathogenic bacteria.