Imipenem Mixture w/ Cilastatin

- Overview
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    Background
    
    β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases. Like many members of the carbapenem subgroup, imipenem is highly resistant to β-lactamase activity.
- Properties
  - CAS Number
    
    74431-23-5; 82009-34-5
    
    Molecular Formula
    
    C12H17N3O4S • H2O ; C16H26N2O5S
    
    Molecular Weight
    
    317.36 ; 358.45
    
    Solubility
    
    Soluble in aqueous solution
    
    Other Properties
    
    PH: 6.5 - 8.5
    Assay: Imipenem: ≥ 400 µg/mg Cilastatin: ≥ 400 µg/mg Imipenem:Cilastatin: 0.95 - 1.05: 1
    Loss on Drying: Not more than 3.5%
    
    Loss on Drying: Not more tha5%
    
    Storage
    
    2-8°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Imipenem is a broad-spectrum antibiotic targeting a wide range of aerobic and anaerobic Gram-positive and Gram-negative bacteria.
    
    Microbiology Applications: Imipenem is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include:
    Pseudomonas aeruginosa 0.25 µg/mL – 12 µg/mL
    Bacteroides fragilis 0.008 µg/mL – 1 µg/mL
    
    Plant Biology Applications: Imipenem has been shown to be effective against bacteria from the genus Burkholderia, a well-described plant pathogen. It has also been shown to be effective for sour skin (onions), slippery skin (bulbs), and cavity disease (mushrooms)(Sojanova et al, 2007).