Geldanamycin - Amerigo Scientific

- Overview
  - Inhibits chaperone protein HSP90; anti-proliferative; antineoplastic
    
    Please contact us at for specific academic pricing.
- Properties
  - Categories
    
    Antibiotics
    
    Alternative Name
    
    9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione 9-carbamate ;(+)-Geldanamycin;NSC 122750
    
    CAS Number
    
    30562-34-6
    
    Molecular Formula
    
    C29H40N2O9
    
    Molecular Weight
    
    560.64 g/mol
    
    MDL Number
    
    MFCD28988736
    
    Note
    
    There is no hazardous surcharge associated with this product.
    There is no special packaging charge associated with this product.
    
    * For research use only. Not for human or veterinary use
- Reference
  - Supko et al (1995). Preclinical pharmacologic evaluation of geldanamycin as an antitumor agent. Cancer Chemotherapy and Pharmacology, 36(4):305-15.
    Chavany et al (1996). p185erbB2 binds to GRP94 in vivo. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2. Journal of Biological Chemistry. 271(9):4974-7.
    Schneider et al (1996). Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90. Proceedings of the National Academy of Sciences of the United States of America. 10;93(25):14536-41.
    Whitesell and Cook (1996). Stable and specific binding of heat shock protein 90 by geldanamycin disrupts glucocorticoid receptor function in intact cells. Molecular Endocrinology. 10(6):705-12.