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Overview
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Geldanamycin is a selective inhibitor of heat shock protein 90 (Hsp90) and its parplog GRP94. Binds to the ATP site of Hsp90/GRP94 (Kd = 1.2 μM) and inhibits their chaperone activity, which affects numerous downstream client proteins with roles in gene expression, cell proliferation, apoptosis and angiogenesis.
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Overview
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