Geldanamycin

- Overview
  - Geldanamycin is a benzoquinone anti-tumor agent which interacts with the stress induced chaperone protein Hsp90 (heat shock protein 90). Geldanamycin is insoluble in aqueous solution but soluble in DMSO and methanol.
    
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    Background
    
    Geldanamycin binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, it is a potent inhibitor of the nuclear hormone receptor family.
- Properties
  - CAS Number
    
    30562-34-6
    
    Molecular Formula
    
    C29H40N2O9
    
    Molecular Weight
    
    560.64 g/mol
    
    Appearance
    
    Yellow to orange powder
    
    Solubility
    
    DMSO: SolubleMethanol: SolubleMethylene chloride: Soluble Water: 6.34 μg/mL
    
    Other Properties
    
    Source: Streptomyces Hygroscopicus
    Melting Point: 201-203°C
    Purity Level: ≥99.0%
    
    Storage
    
    -20 °C, protect from light
    
    * For research use only
- Applications
  - Application Description
    
    Cancer Applications: In normal cells, Hsp90 stabilizes and folds proteins, however, in tumor cells, Hsp90 activity helps stabilize mutated growth factor and signal proteins which facilitate tumor growth. To prevent this complication, geldanamycin binds to and inactivates Hsp90 in cancerous cells leading to degradation of cancer cell proteins.