Geldanamycin

- Overview
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    Background
    
    Geldanamycin, a crystalline antimicrobial compound derived from the culture filtrates of Streptomyces hygroscopicus var. geldanus var. nova., is a potent and specific inhibitor of heat shock protein 90 (Hsp90) that specifically binds to the unique ATP binding pocket of Hsp90 in a stable and pharmacologically specific manner. As an antimicrobial agent, geldanamycin exhibits moderate activity against protozoa, bacteria and fungi as well as parasite Syphacia oblevata and cell cultures of L-1210 and KB. Recent studies have shown that geldanamycin also inhibits the function of glucocorticoid receptor and endothelium-dependent relaxation of the rat aorta, mesentery and middle artery.
- Properties
  - Alternative Name
    
    [(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
    
    CAS Number
    
    30562-34-6
    
    Molecular Formula
    
    C29H40N2O9
    
    Molecular Weight
    
    560.6
    
    Appearance
    
    A solid
    
    Purity
    
    97.01%
    
    Solubility
    
    insoluble in EtOH; insoluble in H2O; ≥16.9 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. Deng X, Song L, et al. "HAX-1 Protects Glioblastoma Cells from Apoptosis through the Akt1 Pathway." Front Cell Neurosci. 2017 Dec 21;11:420. PMID:29311840
    2. Guo XB, Deng X, et al. "Hematopoietic Substrate-1-Associated Protein X-1 Regulates the Proliferation and Apoptosis of Endothelial Progenitor Cells Through Akt Pathway Modulation." Stem Cells. 2018 Mar;36(3):406-419. PMID:29139175

Geldanamycin

Background

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