Telavancin Hydrochloride

- Overview
  - Telavancin Hydrochloride is the hydrochloride salt of Telavancin, a lipoglycopeptide antimicrobial that has bactericidal activity against Gram-positive bacteria including MRSA. It was derived from Vancomycin, and has superior in vitro activity against glycopeptide-susceptible organisms.
    Telavancin Hydrochloride is very soluble in water.
    
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    Background
    
    Telavancin inhibits the synthesis of bacterial cell walls by binding to the D-Ala-D-Ala terminus of the peptidoglycan in the growing cell wall. It also disrupts bacterial cell membrane potential and permeability since the lipophilic moiety of the compound may interact with the lipid bilayer in the membrane.
- Properties
  - CAS Number
    
    560130-42-9
    
    Molecular Formula
    
    C80H107Cl3N11O27P
    
    Molecular Weight
    
    1792.10
    
    Appearance
    
    White to off-white solid
    
    Solubility
    
    Very soluble in water
    
    Other Properties
    
    Source: Semi-synthetic
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Effective against Gram-positive bacteria such as MRSA, VISA and hVISA strains of S. aureus.
    
    Microbiology Applications: Telavancin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative concentration ranges include:
    Staphyloccus aureus (methicillin-resistant) 0.06-0.5 μg/ml
    Streptococcus pneumonia (penicillin-resistant) 0.015-0.03 μg/ml
    .