Streptozocin

- Overview
  - Streptozocin is an anti-tumor agent commonly used in metastatic cancer of pancreatic islet cells. Streptozocin is freely soluble in aqueous solution (>100 mg/mL).
    
    Please contact us at for specific academic pricing.
    
    Background
    
    Streptozocin acts as an alkylating agent which damages DNA by adding methyl and other alkyl groups which interfere with normal base pairing.
- Properties
  - CAS Number
    
    18883-66-4
    
    Molecular Formula
    
    C8H15N3O7
    
    Molecular Weight
    
    265.22
    
    Appearance
    
    Pale yellow crystalline powder
    
    Other Properties
    
    Source: Streptomyces achromogenes
    Water Content (Karl Fischer): ≤1.0%
    Assay: (As Is): 98.5-101.5%
    Optical Rotation: +39°
    Identification: Passes test
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Eukaryotic Cell Culture Applications: Streptozocin is frequently used to induce diabetes and insulitis for diabetes research in mamalian models.Streptozocin (TOKU-E) was used in a study by Xufeng et al. : Effects of Radix linderae extracts on a mouse model of diabetic bladder dysfunction in later decompensated phase
    
    Cancer Applications: Streptozocin has shown to decrease tumor size and relevant tumor-induced symptoms including hypoglycemia.