Name: Voriconazole
Price: 188.00 USD

- Overview
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    Background
    
    Voriconazole is an inhibitor of 14α-lanosterol demethylase with IC50 value of 53nM [1].
    Voriconazole is a triazole antifungal and a second-generation synthetic derivative of fluconazole. It plays its antifungal role through inhibiting cytochrome P450 (CYP 450)–dependent 14α-lanosterol demethylation, which is a vital step in the membrane ergosterol synthesis of fungi. Voriconazole has a broad antifungal spectrum. It is active against all Candida species, many Aspergillus species and other yeasts, including Cryptococcus neoformans, Trichosporon beigelii, and Saccharomyces cerevisia. Voriconazole is available in both intravenous and oral formulations. Voriconazole undergoes extensive hepatic metabolism via the cytochrome P450 enzymes, primarily CYP2C9 and CYP3A4. In addition, voriconazole also causes some side effects, such as visual disturbances, skin rashes and elevations in hepatic enzyme levels [1, 2].
    
    [1] Sabo JA, Abdel-Rahman SM. Voriconazole: a new triazole antifungal. Ann Pharmacother. 2000 Sep;34(9):1032-43.
    [2] Johnson LB, Kauffman CA. Voriconazole: a new triazole antifungal agent. Clin Infect Dis. 2003 Mar 1;36(5):630-7.
- Properties
  - Alternative Name
    
    (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol
    
    CAS Number
    
    137234-62-9
    
    Molecular Formula
    
    C16H14F3N5O
    
    Molecular Weight
    
    349.31
    
    Appearance
    
    A solid
    
    Purity
    
    99.87%
    
    Solubility
    
    ≥34.9 mg/mL in DMSO; insoluble in H2O; ≥45 mg/mL in EtOH with gentle warming and ultrasonic
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

Voriconazole

Voriconazole

Background

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