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Overview
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Quinine is a naturally occurring chemical compound, a cinchona alkaloid first isolated from the bark of the cinchona tree in 1820. It is a stereoisomer of quinidine which contains an aromatic quinoline and a bicyclic quinuclidine. It functions as a potassium channel blocker and is used as an anti-malarial.
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Background
The mechanism of action of quinine has not been fully resolved. Cell fractionation studies in parasitology have shown that it inhibits hemozoin formation in the parasite cell which allows buildup of cytotoxic heme resulting in death. Quinine also acts as a potassium channel blocker.
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