Name: Pivmecillinam Hydrochloride
Price: 182.00 USD

- Overview
  - Pivmecillinam Hydrochloride undergoes hydrolysis in vivo to produce the parent compound, Mecillinam, a broad-spectrum beta-lactam antibiotic and amidinopenicillin. It is used against Gram-negative bacteria implicated in urinary tract infections.
    
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    Background
    
    Pivmecillinam Hydrochloride is a biologically inactive pivaloyloxymethylpenicillin ester that is hydrolysed in the gut to the active component, Mecillinam. The addition of the pivalate ester enhances antibiotic absorption.
    β-lactams interfere with penicillin binding protein (PBP) activity involved in the final phase of peptidoglycan synthesis. PBP’s catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases.
- Properties
  - CAS Number
    
    32887-03-9
    
    Molecular Formula
    
    C21H33N3O5S ∙ HCl
    
    Molecular Weight
    
    476.03
    
    Appearance
    
    Almost white or yellow powder
    
    Solubility
    
    Freely soluble in water, ethanol (anhydrous), and methanol. Slightly soluble in acetone.
    
    Other Properties
    
    Source: Semi-synthetic
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Pivmecillinam Hydrochloride targets primarily Gram-negative bacteria involved in urinary tract infections. It is active against E. coli with < 2% of these isolates exhibiting resistance. It is also effective against members of the Enterobacteriaceae and fluoroquinolones-resistant Shigella species.