Name: Oxacillin Sodium Salt, USP
Price: 148.00 USD

- Overview
  - Oxacillin Sodium Salt, USP is the sodium salt of Oxacillin, semisynthetic penicillinase-resistant and acid-stable antibiotic of the penicillin class. It is a narrow-spectrum β-lactam antibiotic primarily used against Gram-positive organisms. It can be used to study autolysins and mechanisms of penicillinase resistance.
    
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    Background
    
    β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases. Oxacillin however, is resistant to the degradative effects of β-lactamases.
- Properties
  - CAS Number
    
    7240-38-2 (monohydrate)
    
    Molecular Formula
    
    C19H18N3NaO5S (anhydrous basis)
    
    Molecular Weight
    
    441.43
    
    Appearance
    
    White crystalline powder
    
    Other Properties
    
    Source: Semi-synthetic
    Water Content (Karl Fischer): 3.5-5.0%
    PH: 4.5-7.5
    Assay: (On dried basis): 815-950 µg/mg
    
    Storage
    
    2-8 °C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Oxacillin is used primarily against Gram-positive organisms namely resistant Staphylococcus species.
    
    Microbiology Applications: Oxacillin Sodium is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include:
    Staphylococcus aureus 0.125 µg/mL - 8 µg/mL
    Staphylococcus epidermidis 0.125 µg/mL - 16 µg/mL
    Media Supplements
    Oxacillin can be used as a selective agent in several types of isolation media:
    ORSAB - ORSAB Selective Supplement