Monensin Sodium, USP

- Overview
  - Monensin Sodium, USP is a naturally occurring ionophore, used as a nonhormonal growth promoter and coccidiostat. It is a polyether antibiotic used against Gram-negative bacteria and has antiparasitic activity.
    
    Monensin Sodium Salt is soluble in chloroform, methanol, and other organic solvents and slightly soluble in water.
    
    This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for questions.
    
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    Background
    
    As an ionophore, Monensin can disrupt the natural ion gradients such as Ca2+, Mg2+, K+ and Na+, and affect transmembrane ion transport.
- Properties
  - CAS Number
    
    22373-78-0
    
    Molecular Formula
    
    C36H61NaO11
    
    Molecular Weight
    
    692.85
    
    Solubility
    
    Soluble in chloroform, methanol, and other organic solvents. Slightly soluble in water.
    
    Other Properties
    
    Source: Streptomyces cinnamonensis
    
    Storage
    
    2-8°C
    
    * For research use only
- Applications
  - Application Description
    
    Eukaryotic Cell Culture Applications: Liver microsomes were used to study the P-450 isoenzymes involved in the biotransformation of the ionophore Monensin and how it may be affected by chemotherapeutic agents. Results suggest that P-450 3A can play an important role in the oxidative metabolism of Monensin (Nebbia et al, 1999).