Name: Ofloxacin Hydrochloride
Price: 156.00 USD

- Overview
  - Ofloxacin Hydrochloride is a synthetic, broad-spectrum, second-generation fluoroquinolone antibiotic. It is an analog of nalidixic acid. Ofloxacin Hydrochloride inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. Ofloaxacin was developed by Daiichi Seiyaku.
    
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    Background
    
    Ofloxacin Hydrochloride is a Cytochrome P-450 inhibitor, a DNA Topoisomerase II inhibitor. Fluoroquinolone antibiotics target bacterial DNA gyrase, an enzyme which reduces DNA strain during replication. Because DNA gyrase is required during DNA replication, subsequent DNA synthesis and ultimately cell division is inhibited.
- Properties
  - CAS Number
    
    118120-51-7
    
    Molecular Formula
    
    C18H20FN3O4 • HCl
    
    Molecular Weight
    
    397.83
    
    Appearance
    
    Off-white crystalline powder
    
    Solubility
    
    Sparingly soluble in water
    
    Other Properties
    
    Source: Synthetic
    Purity Level: ≥98%
    
    Storage
    
    2-8°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Ofloxacin is a broad-spectrum antibiotic targeting a wide range of Gram-positive and Gram-negative organisms.
    
    Microbiology Applications: Ofloxacin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram- positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include: Haemophilus influenzae 0.016 µg/mL – 0.063 µg/mL Escherichia coli 0.063 µg/mL – 0.125 µg/mL
    Cancer Applications: Oflaxacin had an inhibitory effect on the proliferation of transitional cell carcinoma cell lines at high concentrations (>200 μg/ml). The effect may be related to impairment of telomerase activity by some unknown mechanism (Yamakuchi M et al, 1997). Ofloxacin inhibite proliferation and DNA synthesis of these 3 human TCC lines (CCSUP, T24, and J82 ) in vitro. Inhibition occurred in a concentration- and time-dependent manner. Inhibition of proliferation and DNA synthesis were assessed via MTT and tritiated thymidine assays.