Cefoxitin Sodium, USP

- Overview
  - Cefoxitin Sodium, USP is the sodium salt of Cefotixin, a cephamycin β-lactam second-generation cephalosporin that is resistant to β-lactamases. Cefoxitin Sodium is freely soluble in aqueous solution.
    
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    Background
    
    Like β-lactams, cephamycins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephamycins is commonly due to cells containing plasmid encoded β-lactamases. Like many cephamycins, Cefoxitin is resistant to β-lactamases.
- Properties
  - CAS Number
    
    33564-30-6
    
    Molecular Formula
    
    C16H16N3NaO7S2
    
    Molecular Weight
    
    449.43
    
    Appearance
    
    White or almost white powder
    
    Solubility
    
    Freely soluble in aqueous solution
    
    Other Properties
    
    Source: Semi-synthetic
    Water Content (Karl Fischer): ≤ 1.0%
    PH: 4.2-7.0
    Assay: Dried Basis: 927 - 970 µg/mg (based on C16H17N3O7S2); 97.5% - 102.0% (based on C16H16N3NaO7S2)
    Heavy Metals: ≤0.002%
    Optical Rotation: +206° to +214°
    Identification: Conforms
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Cefoxitin is a broad-spectrum antibiotic effective against several Gram-positive and Gram-negative bacteria. Like many cephamycins, Cefoxitin is particularly effective against anaerobic bacteria.
    
    Microbiology Applications: Cefoxitin Sodium is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include: Bacteroides fragilis 1 µg/mL – 8 µg/mL Bacillus cereus 8.6 µg/mL