Name: Lincomycin Hydrochloride, EP
Price: 193.00 USD

- Overview
  - Lincomycin Hydrochloride, EP is the hydrochloride form of Lincomycin, provided as the monohydrate. Lincomycin is a naturally occurring lincosamide isolated from Streptomyces licolnensis by researchers at Upjohn in 1962. This class of antibacterial contains a rare amino acid (4-propyl-N-methylprolin) coupled to an equally rare aminomethylthio-octopyranoside sugar. Lincomycin is often incorrectly considered an aminoglycoside but it actually shares little or no structural similarity. It is effective for Gram-positive bacteria and disrupts protein synthesis.
    Lincomycin Hydochloride is soluble in water, methanol and ethanol.
    Lincomycin Hydrochloride, EP conforms to European Pharmacopoeia specifications.
    
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    Background
    
    Lincosamide antibiotics inhibit bacterial growth by targeting the 50S ribosomal subunit preventing peptide bond formation and translocation during protein synthesis. Resistance to Lincomycin is commonly attributed to mutations in 50S rRNA preventing Lincomycin binding allowing the cell to synthesize proteins free of error.
- Properties
  - CAS Number
    
    7179-49-9 (monohydrate); 859-18-7 (anhydrous)
    
    Molecular Formula
    
    C18H34N2O6S · HCl · H2O
    
    Molecular Weight
    
    461.02
    
    Appearance
    
    White or almost white crystalline powder
    
    Solubility
    
    Soluble in water, methanol and ethanol
    
    Other Properties
    
    Source: Streptomyces lincolnensis
    Purity Level: 89.5-102.0%
    
    Storage
    
    2-8 °C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Lincomycin is a narrow-spectrum antibiotic effective against Gram-positive bacteria and protozoa. It is effective for Staphylococcus, Streptococcus, and Bacterioides. It has comparable activity to Erythromycin in vitro.
    
    Microbiology Applications: Lincomycin Hydrochloride is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include:
    Staphylococcus aureus 0.2 µg/mL – 3.2 µg/mL
    Streptococcus pyogenes 0.04 µg/mL – 0.8 µg/mL
    
    Plant Biology Applications: Lincomycin provides a powerful plant selection agent that facilitates recovery of plastid transformants. Cultured Nicotiana cells were used in vitro. Resistant cells are green versus sensitive cells are white on the selective medium. Lincomycin is preferred over other antibiotics for chloroplast transformation because it also inhibits callus formation, greening, and subsequent shoot regeneration (Moll et al, 1990).