Lincomycin Hydrochloride, USP

Lincomycin Hydrochloride, USP

Catalog Number:
M001342350TOK
Mfr. No.:
TOK-L002
Price:
$191
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      • Overview
        • Lincomycin Hydrochloride is the hydrochloride form of Lincomycin, provided as the monohydrate. Lincomycin is a naturally occurring lincosamide isolated from Streptomyces licolnensis by researchers at Upjohn in 1962. This class of antibacterial contains a rare amino acid (4-propyl-N-methylprolin) coupled to an equally rare aminomethylthio-octopyranoside sugar. Lincomycin is often incorrectly considered an aminoglycoside but it actually shares little or no structural similarity. It is effective for Gram-positive bacteria and disrupts protein synthesis.
          Lincomycin is very soluble in water and soluble in methanol and ethanol.

          Lincomycin Hydrochloride conforms to United States Pharmacopoeia specifications.

          Please contact us at for specific academic pricing.

          Background

          Lincosamide antibiotics inhibit bacterial growth by targeting the 50S ribosomal subunit preventing peptide bond formation and translocation during protein synthesis. Resistance to Lincomycin is commonly attributed to mutations in 50S rRNA preventing lincomycin binding allowing the cell to synthesize proteins free of error.

      • Properties
        • CAS Number
          7179-49-9 (monohydrate); 859-18-7 (anhydrous)
          Molecular Formula
          C18H34N2O6S · HCl · H2O
          Molecular Weight
          461.02
          Appearance
          White or off-white crystalline powder
          Solubility
          Soluble in aqueous solution (29.3 mg/mL). Soluble in methanol and ethanol.
          Other Properties
          Source: Streptomyces lincolnensis
          Water Content (Karl Fischer): 3.0 - 6.0%
          PH: 3.0 - 5.5
          Assay: Not less than 790 µg/mg
          Optical Rotation: +135° to +150°
          Identification: IR - Passes test
          Storage
          2-8 °C

          * For research use only

      • Applications
        • Application Description
          Spectrum: Lincomycin is a narrow-spectrum antibiotic effective against Gram-positive bacteria , and protozoa. It is effective agaisnt Staphylococcus, Streptococcus, and Bacterioides. It has comparable activity to Erythromycin in vitro.

          Microbiology Applications: Lincomycin Hydochloride is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include:
          Staphylococcus aureus 0.2 µg/mL – 3.2 µg/mL
          Streptococcus pyogenes 0.04 µg/mL – 0.8 µg/mL

          Plant Biology Applications: Lincomycin provides a powerful plant selection agent that facilitates recovery of plastid transformants. Cultured Nicotiana cells were used in vitro. Resistant cells are green and sensitive cells are white on the selective medium. Lincomycin is preferred over other antibiotics for chloroplast transformation because it also inhibits callus formation, greening, and subsequent shoot regeneration (Moll et al, 1990).

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