Gliotoxin

- Overview
  - Gliotoxin is a potent epithiodioxopiperazine mycotoxin produced by species of Gliocladium, Aspergillus and Penicillium. Gliotoxin inhibits a number of thiol-requiring enzymes and displays antioxidant and immunomodulatory activity.
    
    Gliotoxin is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
    
    Please contact us at for specific academic pricing.
    
    Background
    
    At the cellular level gliotoxin inhibits a broad range of unrelated mechanisms, including inhibition of chymotrypsin-like activity of the 20S proteasome and Ca2+ release from mitochondria, activation of transcription factor NF-κB in response to a variety of stimuli in T and B cells, anti-inflammatory activity, and inhibition of farnesyltransferase and geranylgeranyltransferase. The mode of action appears to be via covalent interaction with proteins through mixed disulphide formation.
- Properties
  - CAS Number
    
    67-99-2
    
    Molecular Formula
    
    C13H14N2O4S2
    
    Molecular Weight
    
    326.0
    
    Appearance
    
    White powder
    
    Storage
    
    -20°C
    
    * For research use only