Dinactin

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Dinactin is a macrotetrolide antibiotic that acts as an ionophore for monovalent cations, such as NH4+, K+, and Rb+. Dinactin has been used to study the membrane properties [1]. Dinactin is considered as an active molecule that S. araujoniae produced to control B. cinerea[2].
    In vitro: Dinactin inhibited T-cell proliferation induced by IL-2, by mAb to CD3, and by mAbs to CD3 plus α-CD28 with identical dose-response curves. The IC50 was 10–20 ng/ml. Dinactin inhibited cytokine production with IC50 values of 10 ng/ml for IL-4 and IL-5, 30 or 60 ng/ml for interferong or IL-2, respectively [3].Dinactin inhibited cytokine production through a post-transcriptional mechanism. Dinactin also reduced pulmonary eosinophilia when administered within 1 d of airway antigen challenge [3].
    
    [1] Laprade R, Grenier F, Pagé-Dansereau M, et al. Carrier-mediated ion transport in lipid bilayer membranes[J]. Canadian journal of biochemistry and cell biology, 1984, 62(8): 738-751.
    [2] Silva L J, Crevelin E J, Souza W R, et al. Streptomyces araujoniae produces a multiantibiotic complex with ionophoric properties to control Botrytis cinerea[J]. Phytopathology, 2014, 104(12): 1298-1305.
    [3] Umland S P, Shah H, Jakway J P, et al. Effects of cyclosporin A and dinactin on T-cell proliferation, interleukin-5 production, and murine pulmonary inflammation[J]. American journal of respiratory cell and molecular biology, 1999, 20(3): 481-492.
- Properties
  - Categories
    
    macrotetrolide antibiotic that acts as an ionophore for monovalent cations.
    
    Alternative Name
    
    (1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-5,23-diethyl-2,11,14,20,29,32-hexamethyl-4,13,22,31,37,38,39,40-octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone
    
    CAS Number
    
    20261-85-2
    
    Molecular Formula
    
    C42H68O12
    
    Molecular Weight
    
    765
    
    Appearance
    
    A film
    
    Purity
    
    Purity ≥95.00%
    
    Solubility
    
    Soluble in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    O=C(O[[email protected]](CC)C[[email protected]]1([H])O[[email protected]@]([[email protected]@H]2C)([H])CC1)[[email protected]](C)[[email protected]@]3([H])CC[[email protected]](C[[email protected]](C)OC([[email protected]]([[email protected]@]4([H])O[[email protected]](C[[email protected]](OC([[email protected]](C)[[email protected]]5([H])O[[email protected]](CC5)([H])C[[email protected]](C)OC2=O)=O)CC)([H])CC4)C)=O)([H])O3
    
    * For Research Use Only

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

Datasheet

Dinactin

Background

Documents

We Also Recommend

BCATc Inhibitor 2

Kanosamine (hydrochloride)

N,N'-Dicyclohexylurea