Tylosin B, EvoPure®

Tylosin B, EvoPure® is a highly purified form of tylosin B (desmycosin). Tylosin B is a metabolite of tylosin A and forms in acidic media.
Tylosin is a macrolide antibiotic that was originally isolated from Streptomyces fradiae by the Lilly Research Laboratories in 1961 from a soil sample collected in Thailand. Tylosin is a mixture of four macrolide antibiotics of which the primary component (>80%) is Tylosin A. To a lesser degree, Tylosin B (desmycosin), Tylosin C (macrocin) and Tylosin D (relomycin) may also be present. Tylosin has broad-spectrum bacteriostatic activity against Gram-positive bacteria and mycoplasma, but much less activity against most Gram-negative bacteria and fungi.
Tylosin has been used to study protein synthesis, abscess prevention in cattle, and mycoplasma infections.

Please contact us at for specific academic pricing.

Background

Tylosin, like other Macrolide antibiotics, is a bacteriostatic compound that reversibly binds to the 23S rRNA in the 50S (L27 protein) ribosome subunit and inhibits mRNA-directed protein synthesis. Tylosin B was shown not to inhibit peptidyl transferase (Poulsen et al., 2000).