Cefradine

- Overview
  - Cefradine (also known as cephradine) is a first generation cephalosporin antibiotic which a has similar anti-bacterial spectrum of activity to cefalexin. Cefradine is freely soluble in aqueous solution at 21.3 mg/mL.
    
    Please contact us at for specific academic pricing.
    
    Background
    
    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.
- Properties
  - CAS Number
    
    38821-53-3
    
    Molecular Formula
    
    C16H19N3O4S•H2O
    
    Molecular Weight
    
    349.40
    
    Appearance
    
    White to yellowish crystalline powder
    
    Other Properties
    
    Source: Semi-synthetic
    Water Content (Karl Fischer): ≤6.0%
    PH: 3.5-6.0
    Assay: (On Dried Basis): 95.0-102.0%
    Optical Rotation: +80° to +90°
    Identification: IR
    
    Storage
    
    -20°C
    
    * For research use only