Milbemycin A3

- Overview
  - Milbemycin A3 belongs to the family of Milbemycins, 16-membered macrocyclic lactone antibiotics with a 6,6-membered spiroketal ring system. Milbemycin A3 is a highly selective and potent nematocide and insecticide. Milbemycin A3 is a major member of a group of analogs containing a 25-methyl substituent. Milbemycin A3 is a metabolite derived from fermentation of the soil bacterium Streptomyces hydroscopicus subsp. aureolarcrimosus. Milbemycins are analogs of the avermectins. Other Milbemycins include Milbemycin B through H.
    Milbemycin A3 is soluble in ethanol, methanol, DMF and DMSO but has poor water solubility.
    
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    Background
    
    Like the closely related avermectins, Milbemycins are thought to act by opening glutamate sensitive and GABA-sensitive chloride channels.
- Properties
  - CAS Number
    
    51596-10-2
    
    Molecular Formula
    
    C31H44O7
    
    Molecular Weight
    
    528.7
    
    Appearance
    
    White solid
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Milbemycin A3 has activity against insects including mites, nematodes, worms, ticks, flights, and agricultural pests.
    
    Plant Biology Applications: Milbemectin is used as an agri-chemical for crop protection in soft fruits, citrus fruit, top fruit, aubergines and others to combat mites and leaf miners.
    
    Insect Biology Applications: Milbemectin is a GABA inhibitor and can act as an agonist of the RDL GABA receptor in Drosophila.