Emodin

- Overview
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    Background
    
    Description:
    IC50 Value: observed at 72 hr were as follows: 66.9 uM, Hep3B cells; 74.36 uM, HepG2 cells; and 101.5 uM, Huh7 cells [1].
    Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a naturally occurring anthraquinone present in the roots and barks of numerous plants, molds, and lichens, and an active ingredient of various Chinese herbs. Emodin exerts antiproliferative effects in cancer cells that are regulated by different signaling pathways.
    in vitro: At 6h after emodin treatment, the levels of GDF15, CYP1A1, CYP1B1, and CYR61 were upregulated [1]. Emodin increased the resting tension of gallbladder smooth muscle strips and inhibited voltage-dependent K(+) current in a dose-dependent manner. When 10 microM emodin was applied to gallbladder smooth muscle cells for 3-6 min., the amplitude of voltage-dependent K(+) current was decreased by 31.5 +/- 0.5% at +40 mV, and this inhibitory effect mostly recovered after washout [2].
    in vivo: Emodin treatment significantly alleviated the severity of the disease, based on the reduced hind paw swelling and clinical scores, compared with untreated CIA mice. Comparing with untreated CIA mice, emodin treatment inhibited the levels of TNF-α and IL-6 in the plasma, PGE2 production, and COX-2 protein expression in synovial tissues in a dose manner [3].
    Clinical trial: N/A
- Properties
  - Categories
    
    Naturally occurring anthraquinone, antiproliferative
    
    Alternative Name
    
    Emodol;Frangula emodin; 1,3,8-trihydroxy-6-methylanthracene-9,10-dione
    
    CAS Number
    
    518-82-1
    
    Molecular Formula
    
    C15H10O5
    
    Molecular Weight
    
    270.24
    
    Purity
    
    98.00%
    
    Solubility
    
    ≥27 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CC1=CC(O)=C2C(C(C3=CC(O)=CC(O)=C3C2=O)=O)=C1
    
    * For Research Use Only

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

Datasheet

Emodin

Background

Documents

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