Name: GD3-Ganglioside ammonium
Price: Inquiry

- Overview
  - GD3 ganglioside (shown as sodium salt) has a core disaccharide structure (Galβ1,4Glc) with two sialic acids linked α2,3/α2,8 to the non-reducing galactose residue, and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). GD3 ganglioside is a minor ganglioside in most normal tissues but plays a crucial role in the development of the brain; its presence is significantly reduced in adults. However, expression of GD3 ganglioside is increased in pathological conditions, such as, cancers and neurodegenerative disorders (Malisan, 2002). GD3 ganglioside was the first cancer-associated ganglioside discovered, that promotes adhesion and invasion of cancers. GD3 ganglioside and GD2 ganglioside are highly expressed in a various malignant cancers and have become potential targets for next-generation cancer therapy (Liu, 2018).
    
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- Properties
  - Categories
    
    Ganglioside Oligosaccharides and Gangliosides
    
    CAS Number
    
    62010-37-1
    
    Molecular Formula
    
    C70H125N3O29·xNH4
    
    Note
    
    There is no hazardous surcharge associated with this product.
    There is no special packaging charge associated with this product.
    
    * For research use only. Not for human or veterinary use
- Reference
  - Ledeen et al (2009) Neurobiology Meets Glycosciences, In: The Sugar Code (Ed: Gabius H. J), pp 495-516, Wiley-VCH, Weinheim.
    Malisan et al (2002), GD3 ganglioside and apoptosis, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1585(2-3), 179-187.
    Liu et al (2018) Ganglioside GD3 synthase (GD3S), a novel cancer drug target, Acta Pharmaceutica Sinica B, 8(5), 713-720,

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