Name: 3-Sialyl Lewis X
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- Overview
  - Sialyl Lewis X (SLeX) is a carbohydrate antigen, related to cell adhesion and it has been shown that inhibition of SLeX synthesis leads to decreased adhesion of trophoblast cells to endometrial epithelial cells (Collins, 2006). Sialyl Lewis X is displayed on the terminus of glycolipids that are present on the surface of white blood cells and it has been shown that SLeX has an important role in inflamation processes. The inital adhesion of white blood cells to a site of injury is mediated by E-selectins which are specific for SLeX. Cell-cell recognition between leukocytes and endothelial cells in blood is believed to occur in part through interactions between lectins and oligosaccharide ligands. SLeX is frequently expressed in human cancer cells and primary tumors. It has been demonstrated that SLeX was involved in the adhesion of tumor cells to vascular endothelium. The potential role of SLeX in the tumor metastatic process has been supported by several clinical studies (Liang, 2016).
    
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- Properties
  - Categories
    
    Blood Groups and Lewis Antigens
    
    Alternative Name
    
    NeuNAc-a2-3Gal-b1-4(Fuc-a1-3)GlcNAc
    
    CAS Number
    
    98603-84-0
    
    Molecular Formula
    
    C31H52N2O23
    
    Molecular Weight
    
    820.74 g/mol
    
    MDL Number
    
    MFCD00270073
    
    Note
    
    There is no hazardous surcharge associated with this product.
    There is no special packaging charge associated with this product.
    
    * For research use only. Not for human or veterinary use
- Reference
  - Collins (2006) Dictionary of Carbohydrates, Chapman&Hall, S-38.
    Liang (2016) Clinicopathological and prognostic significance of sialyl Lewis X overexpression in patients with cancer: a meta-analysis. Onco Targets and Therapy, 9.