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GD3-Ganglioside sodium

GD3-Ganglioside sodium

Catalog Number:
C003138690BIO
Mfr. No.:
OG03922
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      • Overview

        • GD3 (shown as sodium salt) has a core disaccharide structure (Galβ1,4Glc) with two sialic acids linked α2,3/α2,8 to the non-reducing galactose residue and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). GD3 is a minor ganglioside in most normal tissues but plays a crucial role in the development of the brain; it is significantly reduced in adults. However, expression of GD3 is increased in pathological conditions, such as, cancers and neurodegenerative disorders (Malisan, 2002). GD3 was the first cancer-associated ganglioside discovered that promotes adhesion and invasion of cancers. GD3 and GD2 are highly expressed in a various malignant tumours and have become potential targets for next-generation cancer therapy (Liu, 2018).

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      • Properties
        • Categories
          Ganglioside Oligosaccharides and Gangliosides
          CAS Number
          62010-37-1
          Molecular Formula
          C70H125N3O29·xNa
          Molecular Weight
          1,472.74 g/mol
          MDL Number
          MFCD00131134
          Note
          There is no hazardous surcharge associated with this product.
          There is no special packaging charge associated with this product.

          * For research use only. Not for human or veterinary use

      • Reference

        • Ledeen et al (2009) Neurobiology Meets Glycosciences, In: The Sugar Code (Ed: Gabius H. J), pp 495-516, Wiley-VCH, Weinheim.
          Malisan et al (2002), GD3 ganglioside and apoptosis, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1585(2-3), 179-187.
          Liu et al (2018) Ganglioside GD3 synthase (GD3S), a novel cancer drug target, Acta Pharmaceutica Sinica B, 8(5), 713-720,

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