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Overview
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Everolimus is a macrocyclic lactone prepared from Rapamycin. It is an analog of Tacrolimus, and binds to receptor protein FKBP12. It is the most commonly used mTOR inhibitor. Everolimus has been found to have anti-cancer properties, and it can also be used as an immunosuppressive agent.
Everolimus is soluble in ethanol, methanol, DMF and DMSO.Please contact us at for specific academic pricing.
Background
Everolimus binds to receptor protein, Peptidyl-prolyl cis-trans isomerase (FKBP12). The complex then binds to ‘mammalian target of rapamycin’ (mTOR) thus preventing it from interacting with target proteins, inhibiting its downstream signaling. It is more selective for the mTORC1 protein complex compared to the mTOR2, the two complexes that make up the mTOR protein.
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- Properties
- Applications
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Overview