1-Alaninechlamydocin

- Overview
  - 1-Alaninechlamydocin is a cyclic tetrapeptide metabolite containing a single β-amino acid, which was isolated from a Tolypocladium sp. from the Great Lakes. It has anti-cancer properties due to the inhibition of histone deacetylase (HDAC).
    
    1-Alaninechlamydocin is soluble in ethanol, methanol, DMF and DMSO.
    
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    Background
    
    1-Alaninechlamydocin exhibits potent antitumor activity and acts by inhibiting histone deacetylase.
- Properties
  - CAS Number
    
    141446-96-0
    
    Molecular Formula
    
    C27H36N4O6
    
    Molecular Weight
    
    512.6
    
    Appearance
    
    White solid
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Eukaryotic Cell Culture Applications: 1-Alaninechlamydocin reduces proliferation of MIA PaCa-2, PANC-1, and hTERT-HPNE cells (GI50s = 5.3, 14, and 2.0 nM, respectively).
    
    Cancer Applications: 1-Alaninechlamydocin showed antiproliferative/cytotoxic activity in human pancreatic cancer cell line (MIA PaCa-2) at low-nanomolar concentrations. It also induced G2/M cell cycle arrest and apoptosis. Similar to other cyclic epoxytetrapeptides, its inhibitory effect is proposed to be via inhibition of HDAC activity (Du et al, 2014).