Name: Echinocandin B Nucleus Hydrochloride
Price: 536.00 USD

- Overview
  - Echinocandin B Hydrochloride is the hydrochloride salt of a the natural product and lipopeptide antifungal Ehinocandin B. Discovered in 1974 in Germany, it is the first of its class of antifungals called echinocandins. Echinocandin B is a cyclic hexapeptide with a linoleolyl side chain. Anidulafungin is synthesized from Echinocandin B.
    
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    Background
    
    Echinocandin competitively inhibits β-(1,3)-D-glucan synthase, thus inhibits glucan synthesis, an essential component of the fungal cell wall. Changes in the cell wall can lead to eventual cell lysis. It does not affect mammalian cells since they do not contain β-(1,3)-D-glucan.
- Properties
  - CAS Number
    
    1029890-89-8
    
    Molecular Formula
    
    C34H51N7O15 ∙ HCl
    
    Molecular Weight
    
    834.27
    
    Appearance
    
    White or off-white powder
    
    Other Properties
    
    Source: Aspergillus nidulans, Aspergillus rugulosis
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Effective against fungi including Aspergillus spp. and Candida spp. including C. albicans. In generla, MIC90 values are ≤ 2 ug/ml against Candida spp. Resistance mechanisms have not been fully elucidatated. The molecular target is the FKS1 subunit of glucan synthase, thus mutations to this site confer varying degrees of resistance.