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Overview
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Vancomycin B Hydrochloride, EvoPure® is a glycopeptide antibiotic derived from Streptomyces orientalis that was discovered in 1953 from a soil sample found in Borneo. It is effective against gram-positive bacteria such as Staphylococcus aureus, including MRSA. Vancomycin HCl is commonly used in selective media for isolation of gram-negative bacteria as well as studies of nanoparticle transport and antibiotic resistance.
EvoPure® products are purified single antibiotic fractions, most >99% pure. Their high purity can be used to identify or analyze the specifc effects of individual fractions.Please contact us at for specific academic pricing.
Background
Vancomycin B HCl prevents cell wall synthesis by two separate mechanisms. One mechanism prevents N-acetylmuramic acid (NAM) and N-acetylglucosamine (NAG) peptides from linking together forming the peptidoglycan backbone through the incorporation of the Vancomycin B HCl molecule to the D-alanyl-D-alanine terminal. The second mechanism prevents crosslinking between amino acid residues in the peptidoglycan chain altering bacterial cell membrane permeability as well as RNA synthesis.
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Overview