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Overview
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Dequalinium chloride is a quaternary ammonium compound that has been discovered to be an inhibitor of the cytopathic effects of some syndrome viruses. It is able to inhibit the replication of the virus in various clinical isolates and in cell culture models. Dequalinium chloride also inhibits acetylcholine receptor-mediated endocytosis, which is one of the mechanisms by which cells resist infection. The mechanism by which dequalinium chloride inhibits acetylcholine receptor-mediated endocytosis is not yet known, but it has been suggested that it might be due to its inhibitory activity on mitochondrial uncoupler proteins. This property may make dequalinium chloride an effective treatment against bacterial infections and respiratory diseases such as cystic fibrosis and asthma.
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