Clofazimine

- Overview
  - Clofazimine is a unique lipophilic rhimophenazine dye with antibacterial, antimycobacterial, anti-inflammatory, immunsupressive, and antituberculosis properties. It was first synthesized in 1954 by a team at Trinity College, Dublin, and was launched under the trade name Lamprene in 1969 (Novartis).
    
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    Background
    
    The mode of action for the biological activity of Clofazimine is unknown but it is thought to act on neutrophils and monocytes.
- Properties
  - CAS Number
    
    2030-63-9
    
    Molecular Formula
    
    C27H22Cl2N4
    
    Molecular Weight
    
    473.40
    
    Appearance
    
    Red to dark-red crystal or powder
    
    Storage
    
    ≤30°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Clofazimine is active against Gram-positive bacteria including multiple drug resistant (MDR) bacteria, with little to no activity against Gram-negative bacteria. It is also active against Mycobacteria.