Dalbavancin Hydrochloride

- Overview
  - Dalbavancin is a second generation, semi-synthetic lipoglycopeptide antibiotic that is active against Gram-positive bacteria. It was designed to improve upon the natural glycopeptides currently available (vancomycina and teicoplanin) and was launched in 2014. It is used to combat the bacteria causing acute bacterial skin and skin structure infections.
    
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    Background
    
    Dalbavancin HCl disrupts cell wall biosynthesis. It binds to the D-alanyl-D-alanyl residue on growing peptidoglycan chains and prevents transpeptidation. Unlike naturally occurring glycopeptides, Dalbavancin can dimerize and anchors itself in the bacterial membrane whcih improves stabilizationa nd increases its affinity for peptidoglycan.
- Properties
  - CAS Number
    
    171500-79-1
    
    Molecular Formula
    
    C88H100Cl2N10O28 . HCl
    
    Molecular Weight
    
    1853.15
    
    Appearance
    
    Powder
    
    Solubility
    
    slightly soluble in water
    
    Other Properties
    
    Source: Semi-synthetic
    Purity Level: 85% - 105% (anhydrous and free base basis)
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Gram-positive bacteria
    
    Microbiology Applications: Dalbavancin has more potent in vitro bactericidal activity than vancomycin or teicoplanin against many resistant organisms such as MRSA and Methicillin-resistant Staphylococcus epidermidis (MRSE). It is active in vitro against S. pneumonieae, S. pyogenes, vancomycin-Sensitive Enterococcus.