Cefuroxime Free Acid

- Overview
  - Cefuroxime is a semi-synthetic, broad-spectrum, β-lactamase-resistant, second-generation cephalosporin. The compound was patented in 1971. It has increased stability to β-lactamases, which can widen the spectrum so that many organisms that are resistant to cephalosporins in general are susceptible to Cefuroxime.
    Cefuroxime is soluble in water
    
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    Background
    
    Cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBPs are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.
- Properties
  - CAS Number
    
    55268-75-2
    
    Molecular Formula
    
    C16H16N4O8S
    
    Molecular Weight
    
    424.39
    
    Appearance
    
    White or almost white crystalline powder
    
    Solubility
    
    Soluble in water
    
    Other Properties
    
    Source: Semi-synthetic
    
    Storage
    
    2-8°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: It is rapidly bactericidal against Gram-positive bacteria, including penicillinase-producing staphylococci and a wide range of Gram-negative organisms including non-β-lactamase-producing strains. Unlike the majority of cephalosporins, Cefuroxime is highly active agaisnt strains of Haemophilus influenzae, and this activity is maintained against the ampicillin-resistant strains. Ampicillin resistance is due to the production of class III β-lactamase, to which Cefuroxime is completely stable.
    
    Microbiology Applications: Cefuroxime is used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include:
    Haemophilus influenzae: <0.06 － 16 µg/mlStreptococcus pneumoniae: 0.004 - 0.25 µg/ml