Name: Cefuroxime Sodium
Price: 254.00 USD

- Overview
  - Cefuroxime Sodium is a broad-spectrum, semi-synthetic second-generation cephalosporin antibiotic with increased stability to β-lactamases. It is bactericidal against Gram-negative and Gram-positive bacteria. Cefuroxime Sodium is freely soluble in aqueous solution.
    
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    Background
    
    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases. Like many second generation cephalosporins, Cefuroxime is relatively stable in the presence of β-lactamases.
- Properties
  - CAS Number
    
    56238-63-2
    
    Molecular Formula
    
    C16H15N4NaO8S
    
    Molecular Weight
    
    446.37 g/mol
    
    Appearance
    
    White to yellowish crystalline powder
    
    Other Properties
    
    Source: Synthetic
    Water Content (Karl Fischer): ≤3.5%
    PH: 6.0-8.5
    Assay: (Dried Basis): Not less than 86.0%
    Optical Rotation: +55° to +65º
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Cefuroxime Sodium is a broad-spectrum antibiotic targeting a wide variety of Gram-negative and Gram-positive bacteria.
    
    Microbiology Applications: Cefuroxime Sodium is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include: Haemophilus influenzae 0.25 µg/mL – 4 µg/mL Neisseria gonorrhoeae 0.2 µg/mL – 1.6 µg/mL Eukaryotic Cell Culture Applications: Rat erythrocyte glucose-6-phosphate dehydrogenase was found to increase in activity in response to Cefuroxime exposure in vitro (Temel Y et al, 2018). Cell proliferation, cytotoxicity, cell metabolism, and extracellular matrix calcification were assessed after antibiotic treatment. Cefuroxime had no inhibiting effects on osteoblasts with lower concentrations (25-100 ug/ml), but higher concentrations (250-1000 µg/ml) saw an increase in cell proliferation and cytotoxicity, and an inhibition of cell metabolism (Salzmann et al, 2007).