Ceftriaxone free acid

- Overview
  - Ceftriaxone free acid is a semisynthetic third-generation cephalosporin with bactericidal activity. It is used as an antibacterial, and since it can cross the blood-brain barrier, it can also be used to study the central nervous system.
    
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    Background
    
    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases. Like many cephalosporins, Ceftriaxone is resistant to a number of β-lactamases.
- Properties
  - CAS Number
    
    73384-59-5
    
    Molecular Formula
    
    C18H18N8O7S3
    
    Molecular Weight
    
    554.58
    
    Appearance
    
    White or yellowish crystalline powder
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Ceftriaxone free acid is a broad-spectrum antibiotic targeting a wide variety of Gram-positive and Gram-negative bacteria.