Cefmetazole, free acid

- Overview
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    Background
    
    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.
- Properties
  - CAS Number
    
    56796-20-4
    
    Molecular Formula
    
    C15H17N7O5S3
    
    Molecular Weight
    
    471.53
    
    Appearance
    
    White or off-white powder
    
    Other Properties
    
    PH: 2 - 4
    Assay: Not less than 97.0%
    Melting Point: 145°C - 155°C
    Optical Rotation: +80° - +88°
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Cefmetazole is broad spectrum antibiotic targeting a wide range of Gram-positive and Gram-negative bacteria. Cefmetazole is more potent against many Gram-negative enteric flora and pathogens than other first generation cephalosporins.
    
    Microbiology Applications: Cefmetazole is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram positive and Gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include: Bacteroides fragilis 4 μg/mL - 32 μg/mL Propionibacterium acnes 0.06 μg/mL - 0.25 μg/mL