Cefoperazone Free Acid

- Overview
  - Cefoperazone Free Acid is a semi-synthetic, broad-spectrum third-generation cephalosporin. Patented in 1974, it was marketed by Pfizer under the trade name Cefobid. The compound has activity against Pseudomonas. It has a tetrazolyl moiety that confers β-lactamase resistance. Cefoperazone may be used as an analytical standard for the determination of cefoperazone in raw bovine milk.
    Cefoperazone Free Acid is slightly soluble in DMSO and Methanol.
    
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    Background
    
    Cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.
- Properties
  - CAS Number
    
    62893-19-0
    
    Molecular Formula
    
    C25H27N9O8S2
    
    Molecular Weight
    
    645.67
    
    Appearance
    
    White to almost white crystalline powder
    
    Solubility
    
    Slightly soluble in DMSO and methanol
    
    Other Properties
    
    Source: Semi-synthetic
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Cefoperazone Free Acid has broad-spectrum activity, including activity against Pseudomonas. It is effective against a wide variety of Gram-positive and Gram-negative bacteria.
    
    Microbiology Applications: Cefoperazone is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options.
    Representative MIC values include:
    Haemophilus influenzae: 0.12 - 0.25 µg/mlStaphylococcus aereus: 0.125 - 32 µg/mlStreptococcus pneumoniae:≤ 0.007 - 1 µg/ml