Cefadroxil

- Overview
  - Cefadroxil is a first generation cephalosporin antibiotic similar in structure and spectrum as cefalexin and cephradine. Cefadroxil exhibits bactericidal activity against a wide spectrum of bacteria.
    
    Please contact us at for specific academic pricing.
    
    Background
    
    Cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.
- Properties
  - CAS Number
    
    50370-12-2
    
    Molecular Formula
    
    C16H17N3O5S
    
    Molecular Weight
    
    363.39
    
    Appearance
    
    White or almost white powder
    
    Solubility
    
    Water: Freely Soluble
    
    Other Properties
    
    PH: 4.0-6.0
    Assay: (On Dried Basis): 950-1050 µg/mg
    Optical Rotation: +165° to +178°
    Identification: IR, TLC
    
    Storage
    
    -20 °C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Cefadroxil is a broad spectrum antibiotic and has shown to be effective in treating skin and UTI infections caused byStaphylococcus and Streptococcus species.
    
    Microbiology Applications: Cefadroxil is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include: Streptococcus pneumoniae 1 μg/ml - 16 μg/ml Staphylococcus auerus 1 μg/ml - 2 μg/ml