7-Aminocephalosporanic Acid

- Overview
  - 7-Aminocephalosporanic Acid (7-ACA) is a key intermediate in the production of a wide variety of semisynthetic Cephalosporin antibiotics. It is an inhibitor of bacterial (S. aureus) β-lactamase. It is derived from mild acid hydrolysis of Cephalosporin C, catalyzed by GI-7-ACA acylase. Cephalosporin C was isolated in 1950 from Cephalosporium. 7-Aminocephalosporanic Acid can be used as a starting material to synthesize semi-synthetic cephalosporin antibiotics and their intermediates.
    7-Aminocephalosporanic Acid is insoluble in water and DMSO.
    
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    Background
    
    7-Aminocephalosporanic Acid interferes with bacterial cell wall synthesis.
- Properties
  - CAS Number
    
    957-68-6
    
    Molecular Formula
    
    C10H12N2O5S
    
    Molecular Weight
    
    272.28
    
    Appearance
    
    White or off-white powder
    
    Solubility
    
    Insoluble in water and DMSO
    
    Other Properties
    
    PH: 3.0 - 5.0
    Loss on Drying: ≤ 1.0%
    Absorbance: 425nm: ≤ 0.1
    Optical Rotation: ≥ +86°
    Purity Level: ≥ 95.5%
    
    Storage
    
    2-8°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Gram-positive bacteria