Cefquinome Sulfate

- Overview
  - Cefquinome sulfate is the sulfate form of Cefquinome, a semisynthetic, broad-spectrum, fourth-generation aminothiazolyl cephalosporin with pharmacological and antibacterial properties. Cefquinome is resistant to β-lactamases. Cefquinome is safe to use in veterinary research since it is time dependent and has no or minimal post-antibiotic effect.
    
    Please contact us at for specific academic pricing.
    
    Background
    
    Cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to bacterial cell lysis and death. Although resistance to cefquinome is rare, they are active against bacteria carrying the AmpC-type β-lactamase resistance mechanism.
- Properties
  - CAS Number
    
    118443-89-3
    
    Molecular Formula
    
    C23H24N6O5S2 ∙H2SO4
    
    Molecular Weight
    
    626.68
    
    Appearance
    
    White to light yellow powder
    
    Solubility
    
    Slightly soluble in DMSO and methanol. It degrades in aqueous solutions
    
    Other Properties
    
    Source: Semi-synthetic
    Purity Level: ≤ 98%
    
    Storage
    
    2-8°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Broad-spectrum targeting Gram-positive and Gram-negative bacteria including E. coli, Pasteurella spp, Salmonella spp, and Enterobacteriaceae spp.
    
    Microbiology Applications: The antibacterial activity is similar to cefpirome and cefotaxime. Representative MIC values include:E. coli 0.12 µg/ml Salmonella spp. (ampicillin-resistant) 0.06-0.5 µg/ml Pasteurella haemolytica ≤ 0.06 ug/ml
    Eukaryotic Cell Culture Applications: S. aureus is one of the common pathogens to cause subclinical bovine mastitis. Authors analyzed isolates from milk to determine their capacity to produce biofilm (exopolysaccharidic matrix that aids in adherence and colonization, protecting the bacteria from host immune system and antimicrobial action) on bovine primary mammary epithelial cells. They also tested isolates for susceptibility to cefquinome sulfate in the presence of biofilm. They found that in the presence of biofilm no isolates grew, demonstrating its efficacy. After the biofilm was broken by sonication, all isolates were recovered, confirming the protective effect of biofilm (Castilho et al, 2017).