Brefeldin A

- Overview
  - Brefeldin A is a mammalian and plant cell antibiotic involved in protein transport inhibition and tumor apoptosis.
    
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    Background
    
    Brefeldin A inhibits protein transport by preventing accumulation of COPI proteins on the Golgi apparatus which facilitate vesicle fusion from the endoplasmic reticulum (ER). By preventing Golgi-COPI protein function, vesicles from the ER cannot properly fuse with the Golgi to be secreted to destined locations.
- Properties
  - CAS Number
    
    20350-15-6
    
    Molecular Formula
    
    C16H24O4
    
    Molecular Weight
    
    280.36
    
    Appearance
    
    White or almost white powder
    
    Solubility
    
    Acetone: SolubleDMSO: SolubleEthanol: SolubleMethanol: 10 mg/mL, Clear and colorless or light yellow solution Water: Insoluble
    
    Other Properties
    
    Source: Penicillium brefeldianum
    Purity Level: (HPLC): ≥99.0%
    
    Storage
    
    2-8°C
    
    * For research use only
- Applications
  - Application Description
    
    Cancer Applications: Brefeldin A has demonstrated anti-cancer properties by inducing apoptosis in leukemia and colon carcinoma cells.