Validamycin

Validamycin is an antibiotic and fungicidal compound produced by Streptomyces hygroscopicus. Validamycin was first discovered in the broth of Streptomyces hygroscopicus var. limoneus T-7545, which was isolated from a soil sample collected in Akashi City, Hyogo Prefecture, Japan in 1970 (Iwasa et al., 1970), and also discovered 5 years later in the broth of S. hygroscopicus var. jinggangensis Yen. TH82, from a soil sample of Jinggang Mountain in Jiangxi, China.
Validamycin is structurally similar to trehalose and acts as a competitive inhibitor for the enzyme trehalase, which is widely spread among animals, plants, insects, and microorganisms. Trehalase enzymes are responsible for trehalose degradation and serves an important role in regulation of such mechanisms as the active transport of glucose into the intestines, reserve supply of energy, gemination of spores, etc. Validamycin is used to study trehalose biosynthesis and trehalase activity.
Validamycin is soluble in water, methanol, DMSO, DMF, acetone, and ethanol.

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Background

Validamycin is structurally similar to trehalose and acts as a competitive inhibitor for trehalase, which is the enzyme responsible for trehalose degradation and serves an important role in regulation of such mechanisms as the active transport of glucose into the intestines, reserve supply of energy, gemination of spores, etc.