Name: Trimethoprim Lactate
Price: 237.00 USD

- Overview
  - Trimethoprim Lactate is a synthetic derivative of trimethoxybenzyl-pyrimidine with bacteriostatic and antiprotozoal properties. As a pyrimidine inhibitor of bacterial dihydrofolate reductase, Trimethoprim binds tightly to the bacterial enzyme, blocking the production of tetrahydrofolic acid from dihydrofolic acid, arresting folic acid synthesis.
    When Trimethroprim Lactate is combined with sulfonamides like Sulfamethoxazole (S045) the compounds show bactericidal effects, but are only bacteriostatic when used separately. The activity is attributed to their synergistic effect in inhibiting folic acid metabolism in bacteria.
    Trimethoprim Lactate has a wide antibacterial spectrum and is active against most Gram-positive and Gram-negative aerobic bacteria, including Nocardia, Brucella, Gram-negative bacilli, and some Gram-positive bacteria like Streptococcus, Toxoplasma and some other coccidians. It is used to treat recurrent cystitis, mild acute prostatitis, urinary tract infections, asymptomatic bacteriuria during pregnancy and respiratory tract infections. Trimethoprim Lactate is freely soluble in aqueous solution.
    
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    Background
    
    Trimethoprim Lactate acts by interfering with the action of bacterial dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. Tetrahydrofolic acid is an essential precursor in the de novo synthesis of the intermediate Thymidine monophosphate (dTMP), precursor of DNA metabolite Thymidine triphosphate.
- Properties
  - CAS Number
    
    23256-42-0
    
    Molecular Formula
    
    C14H18N4O3 · C3H6O3
    
    Molecular Weight
    
    380.40
    
    Appearance
    
    White or off-white powder
    
    Solubility
    
    Freely soluble in aqueous solution
    
    Other Properties
    
    Assay (On dried basis) - Not less than 99.0%
    Residue On Ignition: Not more than 0.1%
    Heavy Metals: Not more than 20 ppm
    Loss on Drying: Not more than 1.0%
    Identification: Positive
    Purity Level: ≥98.0%
    
    Storage
    
    2-8 °C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Trimethoprim Lactate has a wide antibacterial spectrum and is active against most Gram-positive and Gram-negative aerobic bacteria, including Nocardia, Brucella, Gram-negative bacilli, and some Gram-positive bacteria like Streptococcus, Toxoplasma and some other coccidians. It is used to treat recurrent cystitis, mild acute prostatitis, urinary tract infections, asymptomatic bacteriuria during pregnancy and respiratory tract infections.
    
    Microbiology Applications: Trimethoprim Lactate is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include:
    Escherichia coli 0.25 µg/mL - 64 µg/mL
    Haemophilus influenzae 0.15 µg/mL - 16 µg/mL
    
    Plant Biology Applications: Trimethoprim Lactate can be used in combination with rifampicin to provide sufficient coverage against pathogenic microbes. When used without other supplemental antibiotics, trimethoprim was not shown to provide sufficient coverage (Pollock et al, 1983).