Bleomycin A2 Sulfate, EvoPure®

- Overview
  - Bleomycin A2 Sulfate, EvoPure® is a glycopeptide antibiotic used as a chemotherapeutic agent in Hodgkin's lymphoma. Bleomycin A2 is structurally similar to the other compound found in Bleomycin (Bleomycin B2) and differs only by a terminal amine group.
    EvoPure® products have been fully characterized by spectral analysis and are shipped with a comprehensive certificate of analysis containing lot-specific HPLC, MS, HNMR, and FTIR data.
    
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    Background
    
    The mechanism of action of Bleomycin is not well defined; however, it is thought to chelate metallic ions to decrease enzyme activity and stability. This effect is believed to cause enzymes to react with oxygen producing free radicals which cause single-strand breaks in deoxyribose sugar.
- Properties
  - CAS Number
    
    9041-93-4; 11116-31-7 (Bleomycin A2 base)
    
    Molecular Formula
    
    C55H84N17O21S3 · xH2SO4 (lot specific)
    
    Molecular Weight
    
    1415.55 (Free base)
    
    Appearance
    
    White or off-white crystalline powder
    
    Solubility
    
    Water: 20 mg/mL
    
    Other Properties
    
    Source: Streptomyces verticillus
    PH: 4.5-6.0
    Loss on Drying: ≤6.0%
    Identification: IR, MS, NMR
    Purity Level: ≥96.0%
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Plant Biology Applications: Bleomycin has been used in gene selection of tobacco, as only plants containing the ble resistance gene were able to survive in the presence of Bleomycin (Miki et al, 2003).
    
    Cancer Applications: Common treatment for Hodgkin's lymphoma