Atovaquone

- Overview
  - Atovaquone is a hydroxynaphthoquinone antimicrobial compound with antipneumocystic and anti-parasitic properties.
    
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    Background
    
    Atovaquone inhibits cytochrome bc1 of the electron transport system leading to failure of mitochondrial function.
- Properties
  - CAS Number
    
    95233-18-4
    
    Molecular Formula
    
    C22H19ClO3
    
    Molecular Weight
    
    366.837
    
    Appearance
    
    Yellow powder
    
    Solubility
    
    Freely soluble in N-methyl-2-pyrolidone and in tetrahydrofuran; slightly soluble in ethyl acetate; insoluble in water
    
    Other Properties
    
    Source: Synthetic
    Water Content (Karl Fischer): Not more than 1.0%
    Assay: (HPLC): 97.5% - 101.5%
    Residue On Ignition: Not more than 0.1%
    Heavy Metals: Not more than 10ppm
    Identification: IR, HPLC - Passes test
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Atovaquone is active against Plasmodium spp, Pneumocystis carinii, and Toxoplasma gondii in vivo and in vitro.