Amodiaquine Hydrochloride

- Overview
  - Amodiaquine Hydrochloride is a synthetic,4-aminoquinoline compound with anti-malarial and anti-inflammatory properties. It is a histamine-N-methyltransferase inhibitor that was developed in 1948. Amodiaquine Hydrochloride is a congener of chloroquine and its mechanism of action is similar. Its active metabolite is N-desethylamodiaquine.
    Amodiaquine Hydrochloride is soluble in DMSO.
    
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    Background
    
    The mechanism of action for Amodiaquine is not entirely clear; however, it is thought to inhibit digestion of hemoglobin in malarial parasites, inhibiting heme polymerase activity. The result is an accumulation of free heme, which is toxic to the parasite.
- Properties
  - CAS Number
    
    6398-98-7
    
    Molecular Formula
    
    C20H22ClN3O •2HCl •2H2O
    
    Molecular Weight
    
    464.81
    
    Appearance
    
    Yellow crystalline powder
    
    Solubility
    
    DMSOEthanolMethanol
    
    Other Properties
    
    Source: Synthetic
    Water Content (Karl Fischer): 7.0-9.0%
    Assay: (On Dried Basis): 97.0-103.0%
    Residue On Ignition: ≤0.2%
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Amodiaquine has a similar spectrum of activity as chloroquine (Plasmodium vivax, Plasmodium malariae) however; it has shown to be more effective against chloroquine-resistant Plasmodium falciparum.