Apramycin Sulfate

- Overview
  - Apramycin sulfate is an aminoglycoside antibiotic which binds the deep groove of RNA and effectively inhibits ribosomal translocation prohibiting protein synthesis. It is sparingly soluble in water (25 mg/mL).
    
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    Background
    
    Apramycin sulfate binds to the deep groove of RNA and effectively inhibits ribosomal translocation prohibiting protein synthesis.
- Properties
  - CAS Number
    
    65710-07-8
    
    Molecular Formula
    
    C21H41N5O11 • H2SO4
    
    Molecular Weight
    
    637.66
    
    Appearance
    
    Light yellow powder
    
    Other Properties
    
    Source: Streptomyces tenebraius
    Assay: (On Dried Basis): ≥550 units/mg
    Residue On Ignition: ≤1.0%
    Loss on Drying: ≤10.0%
    Identification: Passes test
    
    Storage
    
    2-8°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Gram negative bacteria such as E. coli and Salmonella spp. demonstrate susceptibility to apramycin sulfate.
    
    Microbiology Applications: Apramycin sulfate is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include: Escherichia coli 1 µg/mL － >512 µg/mL Klebsiella pneumoniae 2 µg/mL － >256 µg/mL