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Overview
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Apramycin is a structurally unique broad-spectrum aminoglycoside with a bicyclic sugar moiety and a monosubstituted deoxystreptamineactive. Apramycin inhibits the translocation step of bacterial protein synthesis and induces translation errors. Apramycin is marketed for veterinary use for Gram negative bacteria. Resistance to Apramycin is conferred by production of ribosomal acetyltransferase.
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