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Overview
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Friend leukemia integration 1 transcription factor (FLI-1) is a protein encoded by the proto-ocogeneFLI-1. The FLI-1 protein is best known for its critical role in the pathogenesis of ES/pPNET. FLI-1 isnormally expressed in endothelial cells and in hematopoietic cells, including T-lymphocytes. Theimmunohistochemical detection of FLI-1 protein has been shown in studies to be valuable in thediscrimination of Ewing sarcoma/peripheral primitive neuroectodermal tumor (ES/pPNET) from most ofits potential mimics. ES/pPNET is a rare primary tumor of the bone/soft tissue that resembles otherundifferentiated tumors.
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